UIMC1 and FANCG

Data Source:
BioGRID (fluorescent resonance energy transfer)

		UIMC1	FANCG
Description		ubiquitin interaction motif containing 1	FA complementation group G
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex	Nucleoplasm Nucleolus Mitochondrion Cytosol Plasma Membrane Fanconi Anaemia Nuclear Complex
	Molecular Function	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Damaged DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Ovarian Follicle Development DNA Repair Cellular Response To DNA Damage Stimulus Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Fanconi Anemia Pathway
Drugs
Diseases			Fanconi anemia
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3	44 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TCEANC TFIP11 TLE5 TPRX1 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1
Entrez ID		51720	2189
HPRD ID		11482	04262
Ensembl ID		ENSG00000087206	ENSG00000221829
Uniprot IDs		A0A024R7R0 Q96RL1	O15287 Q53XM5
PDB IDs		2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?
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