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FANCG and HES1
Data Source:
HPRD
(two hybrid, in vivo)
FANCG
HES1
Description
FA complementation group G
hes family bHLH transcription factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Nucleolus
Mitochondrion
Cytosol
Plasma Membrane
Fanconi Anaemia Nuclear Complex
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Molecular Function
Damaged DNA Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Ovarian Follicle Development
DNA Repair
Cellular Response To DNA Damage Stimulus
Mitochondrion Organization
Spermatid Development
Response To Radiation
Interstrand Cross-link Repair
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Pathways
Fanconi Anemia Pathway
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
Fanconi anemia
GWAS
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
32888494
)
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
44 interacting genes:
BRCA2
BRCC3
CAPN1
CBY2
CDK1
COG6
CTBP1
CYP19A1
CYP2E1
DOK5
ERCC4
FANCA
FANCC
FANCE
FANCF
FTSJ3
GABPB1
GATA1
GOLGA2
HES1
HGS
IHO1
IKZF3
KRT13
KRT19
LNX2
MEOX2
NECAB2
NLGN3
PSMB1
RINT1
RTN2
SAMD3
SSX2IP
TADA2A
TCEANC
TFIP11
TLE5
TPRX1
UIMC1
USHBP1
XRCC3
ZBED1
ZBTB1
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
2189
3280
HPRD ID
04262
00770
Ensembl ID
ENSG00000221829
ENSG00000114315
Uniprot IDs
O15287
Q53XM5
Q14469
PDB IDs
2MH3
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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