UIMC1 and ABRAXAS1

Data Source:
HPRD (in vitro, in vivo)

		UIMC1	ABRAXAS1
Description		ubiquitin interaction motif containing 1	abraxas 1, BRCA1 A complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex
	Molecular Function	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Attachment Of Spindle Microtubules To Kinetochore Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Protein K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint Mitotic Spindle Assembly
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3	5 interacting genes: BRCA1 SUMO2 UBC UIMC1 ZMYM3
Entrez ID		51720	84142
HPRD ID		11482	08584
Ensembl ID		ENSG00000087206	ENSG00000163322
Uniprot IDs		A0A024R7R0 Q96RL1	D6REL5 Q6UWZ7
PDB IDs		2MKF 2MKG 2N9E 2RR9	4JLU 4U4A 4Y18 4Y2G
Enriched GO Terms of Interacting Partners?
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