FANCG and FTSJ3

Data Source:
BioGRID (two hybrid)

		FANCG	FTSJ3
Description		FA complementation group G	FtsJ RNA 2'-O-methyltransferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Plasma Membrane Fanconi Anaemia Nuclear Complex	Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor Preribosome, Small Subunit Precursor
	Molecular Function	Damaged DNA Binding Protein Binding	RNA Binding Protein Binding RNA Methyltransferase Activity RRNA (uridine-2'-O-)-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RNA 2'-O-methyltransferase Activity
	Biological Process	Ovarian Follicle Development DNA Repair Cellular Response To DNA Damage Stimulus Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair	Enzyme-directed RRNA 2'-O-methylation Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Methylation RRNA Methylation
Pathways		Fanconi Anemia Pathway	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Fanconi anemia
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)	Hemoglobin levels ( 32327693)
Interacting Genes		44 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TCEANC TFIP11 TLE5 TPRX1 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1	8 interacting genes: CSNK2A1 EIF2AK2 FANCG MAGEB4 OAS3 SAT1 SSX2 SSX2B
Entrez ID		2189	117246
HPRD ID		04262	17024
Ensembl ID		ENSG00000221829	ENSG00000108592
Uniprot IDs		O15287 Q53XM5	Q8IY81
PDB IDs
Enriched GO Terms of Interacting Partners?
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