ANKFY1 and RAB5A

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ANKFY1	RAB5A
Description		ankyrin repeat and FYVE domain containing 1	RAB5A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Cytosol Endosome Membrane Membrane Retromer Complex Intracellular Membrane-bounded Organelle Macropinosome Extracellular Exosome	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Small GTPase Binding Metal Ion Binding Phosphatidylinositol Phosphate Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Endosomal Transport Endosomal Vesicle Fusion Retrograde Transport, Endosome To Golgi Positive Regulation Of Pinocytosis Golgi To Lysosome Transport	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Endocytosis Phagocytosis Blood Coagulation Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Post-translational Protein Modification Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Membrane Organization Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways			Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production
Drugs			L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Diastolic blood pressure ( 30578418) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Hematocrit ( 32888494) Refractive error ( 32231278)	Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		7 interacting genes: ANKRD28 CLK1 EHD1 RAB5A RHOD RHOF SRPK2	35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL
Entrez ID		51479	5868
HPRD ID		09717	01542
Ensembl ID		ENSG00000185722	ENSG00000144566
Uniprot IDs		B3KPZ0 Q9P2R3	A0A024R2K1 P20339
PDB IDs			1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U
Enriched GO Terms of Interacting Partners?
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