RAB5A and RAB37

Data Source:
HPRD (two hybrid)

		RAB5A	RAB37
Description		RAB5A, member RAS oncogene family	RAB37, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane	Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Azurophil Granule Membrane Specific Granule Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Endocytosis Phagocytosis Blood Coagulation Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Post-translational Protein Modification Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Membrane Organization Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Protein Transport Neutrophil Degranulation
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production	Neutrophil degranulation RAB geranylgeranylation
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL	5 interacting genes: EWSR1 MAL2 RAB5A RABGGTB RIMS1
Entrez ID		5868	326624
HPRD ID		01542	06702
Ensembl ID		ENSG00000144566	ENSG00000172794
Uniprot IDs		A0A024R2K1 P20339	A0A024R8K6 B3KPZ5 B7Z3L0 Q96AX2
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U
Enriched GO Terms of Interacting Partners?
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