RNF138 and UBE2K

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		RNF138	UBE2K
Description		ring finger protein 138	ubiquitin conjugating enzyme E2 K
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Site Of Double-strand Break	Nucleus Cytosol Filopodium Tip
	Molecular Function	Single-stranded DNA Binding Protein Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Wnt Signaling Pathway Protein Ubiquitination Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		15 interacting genes: APP CFAP206 EFEMP2 LNX2 NTAQ1 PCBP4 QKI RAD51D TAF9 TCF7L2 TRIM8 UBE2D2 UBE2D4 UBE2K UBE2W	95 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM63 TSN UBA1 UBB UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		51444	3093
HPRD ID		11508	04165
Ensembl ID		ENSG00000134758	ENSG00000078140
Uniprot IDs		A0A140VJT9 Q8WVD3	B3KSH4 B4DIZ2 P61086
PDB IDs			1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7
Enriched GO Terms of Interacting Partners?
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