ACTL6B and CTBP1

Data Source:
HPRD (two hybrid, in vivo)

		ACTL6B	CTBP1
Description		actin like 6B	C-terminal binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus SWI/SNF Complex NuA4 Histone Acetyltransferase Complex NBAF Complex	Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Structural Constituent Of Cytoskeleton	RNA Polymerase II Transcription Corepressor Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Nervous System Development Dendrite Development Spinal Cord Development Neuron Maturation ATP-dependent Chromatin Remodeling Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Histone H4 Acetylation
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes Signaling by TCF7L2 mutants
Drugs			Formic acid
Diseases
GWAS		Hematocrit ( 29403010 28017375) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 32888494 28017375) Mean corpuscular volume ( 29403010 32888494 28017375) Red blood cell count ( 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414)	Type 2 diabetes ( 31118516 32499647)
Interacting Genes		12 interacting genes: ANXA7 APP ATM CDKN1A COQ9 CSNK2B CTBP1 GSK3B PLK1 SMARCA2 SMN1 TK1	92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		51412	1487
HPRD ID		12419	04015
Ensembl ID		ENSG00000077080	ENSG00000159692
Uniprot IDs		O94805	Q13363 X5D8Y5
PDB IDs			1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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