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CTBP1 and CDKN2D
Data Source:
BioGRID
(two hybrid)
CTBP1
CDKN2D
Description
C-terminal binding protein 1
cyclin dependent kinase inhibitor 2D
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Transcription Repressor Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cyclin D2-CDK4 Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Domain Specific Binding
Identical Protein Binding
NAD Binding
Repressing Transcription Factor Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Silencing
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Viral Genome Replication
Positive Regulation Of Histone Deacetylation
Negative Regulation Of Histone Acetylation
Negative Regulation Of Transcription, DNA-templated
White Fat Cell Differentiation
Regulation Of Cell Cycle
Negative Regulation Of Histone H4 Acetylation
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
Cell Cycle Arrest
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Response To UV
Negative Regulation Of Cell Growth
Response To Retinoic Acid
Response To Vitamin D
Negative Regulation Of Phosphorylation
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Autophagic Cell Death
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Deactivation of the beta-catenin transactivating complex
SUMOylation of transcription cofactors
Repression of WNT target genes
Signaling by TCF7L2 mutants
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Drugs
Formic acid
Diseases
GWAS
Type 2 diabetes (
31118516
32499647
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
92 interacting genes:
ACTL6B
AKAP9
APC
ARNT2
ATXN1L
BCAS3
BCL3
BMPR2
BRCA1
CBX4
CDC23
CDKN2D
CEP68
CHD3
CREBBP
CRY2
CTBP2
CTNNA1
DGCR6
DMRTB1
EEF1D
ELAC2
ELK3
EP300
FANCC
FANCF
FANCG
FANCL
FOXP1
FOXP2
FUNDC1
GTF2B
H3-4
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
HDAC9
HEMGN
HIC1
HOXB5
HTT
IKZF1
IKZF2
KAT2B
KDM1A
KLF12
KLF3
LCORL
LNX1
MAML2
MAPK9
MARCHF10
MECOM
NME2
NOL4
NOL4L
NOS1
NRIP1
NTAQ1
ORC4
PIAS2
PLCB1
PNN
PRKAA1
PRKCI
RAI2
RB1
RBBP5
RBBP8
RBM14
RCOR1
RNF111
SIN3A
SNRPN
SOBP
SPEN
TBP
TCF4
TEAD4
TERF2
TERF2IP
TGIF1
THAP11
TSHZ3
ZBP1
ZBTB18
ZEB1
ZEB2
ZFPM2
ZNF219
63 interacting genes:
APP
BRCA1
BTG1
C1orf94
C5orf49
CCND3
CDK4
CDK6
CGGBP1
CTBP1
DDIT4L
DMRTB1
DYNLT2B
EIF4G1
FAM228A
FAM86C1P
FHL3
GATAD2B
GLYR1
GORASP2
GSC2
HSD17B14
IKZF3
INCA1
KRT75
LNX1
LONRF1
LSM3
MEI4
MEOX2
MSS51
MTF2
NDUFB7
NIF3L1
NME4
NMI
NR4A1
NR4A2
NR4A3
PICK1
PRDX5
PRIMPOL
PSMA1
QKI
REL
RUFY4
SAXO1
SDCBP
SH3GLB1
SH3GLB2
TBC1D17
TEX11
THAP1
TSG101
TSGA10IP
UQCC2
VGLL1
YPEL3
ZBTB32
ZNF396
ZNF620
ZNF688
ZNF774
Entrez ID
1487
1032
HPRD ID
04015
02957
Ensembl ID
ENSG00000159692
ENSG00000129355
Uniprot IDs
Q13363
X5D8Y5
A0A024R796
P55273
PDB IDs
1MX3
4LCE
4U6Q
4U6S
6CDF
6CDR
1BD8
1BI8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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