HOOK1 and VPS18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HOOK1	VPS18
Description		hook microtubule tethering protein 1	VPS18 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex FHF Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Multicellular Organism Development Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		30 interacting genes: AKTIP ANK3 ANKRD23 CDC5L CDK4 CWF19L2 FAM161A FHIP1B HOOK2 HOOK3 LMO2 MEOX2 PIAS2 SYCE1 TBC1D7 TFIP11 USP2 UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45
Entrez ID		51361	57617
HPRD ID		07428	09776
Ensembl ID		ENSG00000134709	ENSG00000104142
Uniprot IDs		Q9UJC3	A0A024R9R3 Q9P253
PDB IDs
Enriched GO Terms of Interacting Partners?
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