VPS18 and MON1B

Data Source:
BioGRID (two hybrid, pull down)

		VPS18	MON1B
Description		VPS18 core subunit of CORVET and HOPS complexes	MON1 homolog B, secretory trafficking associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Actin Filament AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane CORVET Complex Presynapse Glutamatergic Synapse	Cytoplasm Mon1-Ccz1 Complex
	Molecular Function	Actin Binding Protein Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Lysosome Organization Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of SNARE Complex Assembly Viral Entry Into Host Cell Regulation Of Synaptic Vesicle Exocytosis	Protein Targeting To Vacuole Vesicle-mediated Transport Early Viral Transcription Late Viral Transcription
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Malaria ( 31844061) Refractive error ( 32231278) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Immune response to measles-mumps-rubella vaccine ( 24811271) Metabolite levels ( 23823483) Multisite chronic pain ( 31194737) Number of sexual partners ( 30643258)
Interacting Genes		20 interacting genes: AKTIP COPB1 EP300 GGA1 GGA2 GGA3 HOOK1 MON1B RAB7A RILP STX1A STX6 STX7 STX8 UBE2D2 UVRAG VPS11 VPS16 VPS33A VPS45	6 interacting genes: RABGEF1 VPS11 VPS16 VPS18 VPS33A VPS41
Entrez ID		57617	22879
HPRD ID		09776	12342
Ensembl ID		ENSG00000104142	ENSG00000103111
Uniprot IDs		A0A024R9R3 Q9P253	B4DKA0 E7EW32 Q6ZR87 Q7L1V2
PDB IDs
Enriched GO Terms of Interacting Partners?
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