HOOK1 and VPS41

Data Source:
HPRD (in vivo)

		HOOK1	VPS41
Description		hook microtubule tethering protein 1	VPS41 subunit of HOPS complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex FHF Complex	Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Microtubule Cytoskeleton AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane Clathrin Complex
	Molecular Function	Actin Binding Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Protein Binding Microtubule Binding Identical Protein Binding Protein Self-association Metal Ion Binding
	Biological Process	Golgi Organization Endosome Organization Lysosome Organization Multicellular Organism Development Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Manchette Assembly	Protein Targeting To Vacuole Endosome To Lysosome Transport Cellular Response To Starvation Macroautophagy Endosomal Vesicle Fusion Regulated Exocytosis Late Endosome To Lysosome Transport
Pathways
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)
Interacting Genes		30 interacting genes: AKTIP ANK3 ANKRD23 CDC5L CDK4 CWF19L2 FAM161A FHIP1B HOOK2 HOOK3 LMO2 MEOX2 PIAS2 SYCE1 TBC1D7 TFIP11 USP2 UTP14C VPS16 VPS18 VPS39 VPS41 ZBTB47 ZNF250 ZNF35 ZNF572 ZNF655 ZNF764 ZNF785 ZNF80	12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B
Entrez ID		51361	27072
HPRD ID		07428	10402
Ensembl ID		ENSG00000134709	ENSG00000006715
Uniprot IDs		Q9UJC3	P49754
PDB IDs
Enriched GO Terms of Interacting Partners?
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