PCSK1 and PMCH

Data Source:
HPRD (in vivo)

		PCSK1	PMCH
Description		proprotein convertase subtilisin/kexin type 1	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection	Extracellular Region Nucleus Synapse
	Molecular Function	Serine-type Endopeptidase Activity Identical Protein Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Insulin pork
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5122	5367
HPRD ID		01201	01459
Ensembl ID		ENSG00000175426	ENSG00000183395
Uniprot IDs		P29120	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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