PMCH and PCSK2

Data Source:
HPRD (in vivo)

		PMCH	PCSK2
Description		pro-melanin concentrating hormone	proprotein convertase subtilisin/kexin type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Synapse	Extracellular Space Nucleoplasm Membrane Transport Vesicle Secretory Granule Dendrite Neuron Projection Perikaryon Intracellular Membrane-bounded Organelle
	Molecular Function	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding	Serine-type Endopeptidase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation	Proteolysis Nervous System Development Protein Processing Peptide Hormone Processing Protein Autoprocessing Insulin Processing Enkephalin Processing Islet Amyloid Polypeptide Processing
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Insulin processing
Drugs			Insulin pork
Diseases
GWAS		Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)	Biochemical measures ( 19260141) Body size at age 10 ( 32376654) Chronotype ( 30696823) Dialysis-related mortality ( 21546767) Familial lung cancer ( 29924316) Loneliness ( 27629369) Menarche (age at onset) ( 21102462 25231870) Morning person ( 30696823) Obesity-related traits ( 23251661) Preschool internalizing problems ( 24839885) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7	3 interacting genes: IAPP PMCH SCG5
Entrez ID		5367	5126
HPRD ID		01459	01202
Ensembl ID		ENSG00000183395	ENSG00000125851
Uniprot IDs		P20382	P16519
PDB IDs
Enriched GO Terms of Interacting Partners?
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