PCSK1 and PCSK1N

Data Source:
HPRD (in vitro)

		PCSK1	PCSK1N
Description		proprotein convertase subtilisin/kexin type 1	proprotein convertase subtilisin/kexin type 1 inhibitor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection	Extracellular Space Trans-Golgi Network Secretory Granule
	Molecular Function	Serine-type Endopeptidase Activity Identical Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process	Response To Dietary Excess Neuropeptide Signaling Pathway Response To Cold Negative Regulation Of Endopeptidase Activity Peptide Hormone Processing
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Insulin pork
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)	Type 2 diabetes ( 30718926)
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN	2 interacting genes: PCSK1 RAD51
Entrez ID		5122	27344
HPRD ID		01201	02320
Ensembl ID		ENSG00000175426	ENSG00000102109
Uniprot IDs		P29120	Q9UHG2
PDB IDs
Enriched GO Terms of Interacting Partners?
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