PCSK1

Description		proprotein convertase subtilisin/kexin type 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs		Insulin pork
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Novel Interacting Genes		1 novel interacting genes: FER
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN
Entrez ID		5122
HPRD ID		01201
Ensembl ID		ENSG00000175426
Uniprot IDs		P29120
PDB IDs
Enriched GO Terms of Interacting Partners?
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