OTUD3 and HSD17B14

Data Source:
BioGRID (two hybrid)

		OTUD3	HSD17B14
Description		OTU deubiquitinase 3	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Protein Kinase B Signaling Protein K48-linked Deubiquitination Protein K27-linked Deubiquitination	Estrogen Biosynthetic Process Steroid Catabolic Process
Pathways		Ovarian tumor domain proteases Regulation of PTEN stability and activity	Estrogen biosynthesis
Drugs
Diseases
GWAS		group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19915572 28067908 20228798 20228799 19122664 23511034)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		4 interacting genes: HSD17B14 HSPA5 PTEN UBC	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		23252	51171
HPRD ID		19417	16801
Ensembl ID		ENSG00000169914	ENSG00000087076
Uniprot IDs		Q5T2D3	A0A140VJH8 Q9BPX1
PDB IDs		4BOU	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK
Enriched GO Terms of Interacting Partners?
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