ADIPOR1 and APPL1

Data Source:
BioGRID (two hybrid, protein complementation assay)
HPRD (two hybrid, in vivo, in vitro)

		ADIPOR1	APPL1
Description		adiponectin receptor 1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Macropinosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding
	Biological Process	Hormone-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Negative Regulation Of Cell Growth Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of NIK/NF-kappaB Signaling	Protein Import Into Nucleus Cell Cycle Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of Glucose Import Positive Regulation Of Glucose Import Positive Regulation Of Melanin Biosynthetic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity	Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252)
Interacting Genes		6 interacting genes: APPL1 DPH3 NAA20 NFKBIL1 STK11 TBXA2R	64 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBE2O ZNF829
Entrez ID		51094	26060
HPRD ID		06402	05053
Ensembl ID		ENSG00000159346	ENSG00000157500
Uniprot IDs		Q96A54	Q9UKG1
PDB IDs		5LXG 6KRZ 6KS0	2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?
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