SEPSECS and DTX2

Data Source:
BioGRID (two hybrid)

		SEPSECS	DTX2
Description		Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	deltex E3 ubiquitin ligase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	TRNA Binding Protein Binding Transferase Activity, Transferring Selenium-containing Groups	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Selenocysteine Incorporation Selenocysteine Metabolic Process Selenocysteinyl-tRNA(Sec) Biosynthetic Process	Notch Signaling Pathway Protein Ubiquitination
Pathways		Selenocysteine synthesis	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs		Pyridoxal phosphate
Diseases
GWAS		Tonsillectomy ( 27182965 28928442)
Interacting Genes		1 interacting genes: DTX2	131 interacting genes: ABHD11 ABHD16A ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C11orf1 C19orf54 C1orf94 C20orf85 C22orf39 CCDC57 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PPP1R32 PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUSC1 SEC22A SEC23A SEC23B SEPSECS SLC22A18AS SOHLH1 SPAG8 SPG21 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		51091	113878
HPRD ID		11561	16841
Ensembl ID		ENSG00000109618	ENSG00000091073
Uniprot IDs		A1A4F3 Q9HD40	Q86UW9
PDB IDs		3HL2 4ZDL 4ZDO 4ZDP	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?
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