LAP3 and MAPRE3

Data Source:
BioGRID (two hybrid)

		LAP3	MAPRE3
Description		leucine aminopeptidase 3	microtubule associated protein RP/EB family member 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Trans-Golgi Network Cytosol Focal Adhesion Midbody Extracellular Exosome	Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End
	Molecular Function	Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity	Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	Proteolysis	Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Spindle Assembly Cell Division Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end
Pathways
Drugs		Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: APP BANP CBX3 CBX5 LIG4 MAPRE3 PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX	60 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 C4orf45 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GAS2L2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE1 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B TAOK2 TEX43 TLE5 TRAIP TRIM14 TROAP TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547
Entrez ID		51056	22924
HPRD ID		07516	16156
Ensembl ID		ENSG00000002549	ENSG00000084764
Uniprot IDs		P28838	Q9UPY8
PDB IDs			1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7
Enriched GO Terms of Interacting Partners?
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