LAP3 and CBX5

Data Source:
BioGRID (two hybrid)

		LAP3	CBX5
Description		leucine aminopeptidase 3	chromobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Trans-Golgi Network Cytosol Focal Adhesion Midbody Extracellular Exosome	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	Aminopeptidase Activity Protein Binding Metalloexopeptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding
	Biological Process	Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs		Leucine Phosphonic Acid (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid Zofenoprilat	Copper
Diseases
GWAS			Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: APP BANP CBX3 CBX5 LIG4 MAPRE3 PIH1D2 PIK3R3 TAB1 USF1 ZNF76 ZYX	59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		51056	23468
HPRD ID		07516	05131
Ensembl ID		ENSG00000002549	ENSG00000094916
Uniprot IDs		P28838	P45973 V9HWG0
PDB IDs			3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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