MAPRE3 and LMO2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAPRE3	LMO2
Description		microtubule associated protein RP/EB family member 3	LIM domain only 2
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Midbody Microtubule Plus-end Spindle Midzone Mitotic Spindle Astral Microtubule End	Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Microtubule Binding Protein C-terminus Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding	RNA Polymerase II Activating Transcription Factor Binding Transcription Coregulator Binding Transcription Coactivator Activity Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	Protein Localization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Spindle Assembly Cell Division Positive Regulation Of Microtubule Plus-end Binding Protein Localization To Microtubule Plus-end	Multicellular Organism Development Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cognitive performance ( 19734545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252)
Interacting Genes		60 interacting genes: ANKRD1 APC2 AURKA AURKB C20orf202 C4orf45 CCSER1 CHRDL2 CLASP1 CRTAC1 DCTN2 DDIT4L DOK4 EIF4E2 FAM161B FOXD4L1 FOXD4L4 FXR2 GAS2L2 GTF2F2 GTSE1 HROB IKZF1 JUN KIF19 KLHDC7B KNSTRN LAP3 LHX4 LMO2 MAPRE1 MAPRE2 MARCHF7 MEOX2 MRPL12 PDE4DIP PICK1 POU4F1 PSMA1 PSMB1 PSRC1 RAB1A REL SDCBP SIAH1 SLAIN1 SPDYE2 SPDYE2B TAOK2 TEX43 TLE5 TRAIP TRIM14 TROAP TXN2 YAF2 ZC2HC1A ZC2HC1C ZNF526 ZNF547	188 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 ARHGEF5 ARID5A ARNT2 AXIN1 BANP BCAS2 BEX2 BLZF1 BYSL C1orf109 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DMRT3 DRAP1 DYDC1 EFHC1 EFHC2 EHMT2 EIF3B EIF4EBP1 ELF2 ENKD1 ERBIN FAAP20 FAM214B FAM228A FAM90A1 FHL3 FHL5 GAS8 GATA1 GATA2 GATA3 GFAP GMEB2 GOLGA2 GRB2 HDAC5 HNRNPC HNRNPM HOOK1 ICA1L IFT43 IHO1 IKZF1 IKZF3 INCA1 ISL1 ISY1 KANK2 KAZN KDM5A KIF2A KIF3B KPRP KRT15 KRT34 KRT40 KRT75 KRT80 KRTAP10-7 LDB1 LDB2 LDOC1 LMO4 LMOD3 LYL1 LZTS1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MISP MRFAP1L1 MSN MTUS2 MYOZ3 N4BP2L2 NCAPH2 NDOR1 NDUFAB1 NDUFB7 NFKBID NHLH1 NIF3L1 NOTCH2NLA NOXA1 NSMF NTAQ1 NUP62 NUTM1 PATZ1 PAX9 PBX4 PDE9A PHC2 POLR2G PPP1R32 PRDM6 PRKG1 PSMA1 RBBP8 RCN1 REL RELA RINT1 RLIM ROCK1 RTL8C RUSC1 SAXO1 SGTB SKP1 SMAD2 SMUG1 SNAPC5 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TBX2 TCP10L TEKT3 TFIP11 TFPT THAP6 TLE5 TLX3 TRIB3 TRIM23 TRIM54 TRIM55 TRIM63 TRIP6 TSC1 TSC22D4 TSEN15 TSEN54 TSGA10IP TSPYL2 TSSK3 TUFT1 UBA6 UBASH3B UBE2I USH1G VBP1 VEZF1 VMAC WASF1 WASHC1 YOD1 YPEL3 ZFP64 ZMYND12 ZNF185 ZNF19 ZNF24 ZNF250 ZNF34 ZNF410 ZNF641 ZNF655 ZNF688
Entrez ID		22924	4005
HPRD ID		16156	01586
Ensembl ID		ENSG00000084764	ENSG00000135363
Uniprot IDs		Q9UPY8	P25791
PDB IDs		1WYO 3CO1 3JAK 3JAL 3JAR 3TQ7	2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
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