COPS7A and COPS4

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical)
HPRD (in vitro, in vivo)

		COPS7A	COPS4
Description		COP9 signalosome subunit 7A	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction
	Molecular Function	Protein Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair COP9 Signalosome Assembly Viral Process Post-translational Protein Modification	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Post-translational Protein Modification
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	24 interacting genes: BRME1 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 CUL5 FOS GPS1 IKBKB IL1RN KRT19 MBIP PCDHB12 PEX14 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		50813	51138
HPRD ID		16736	09888
Ensembl ID		ENSG00000111652	ENSG00000138663
Uniprot IDs		Q9UBW8	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		4D10 4D18 4WSN	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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