COPS4 and IL1RN

Data Source:
BioGRID (pull down)

		COPS4	IL1RN
Description		COP9 signalosome subunit 4	interleukin 1 receptor antagonist
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Post-translational Protein Modification	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Interleukin-10 signaling Interleukin-1 signaling
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		24 interacting genes: BRME1 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 CUL5 FOS GPS1 IKBKB IL1RN KRT19 MBIP PCDHB12 PEX14 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ	6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		51138	3557
HPRD ID		09888	00978
Ensembl ID		ENSG00000138663	ENSG00000136689
Uniprot IDs		A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78	A0A024R528 P18510
PDB IDs		4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?
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