COPS7A and NFE2L2

Data Source:
HPRD (in vitro)

		COPS7A	NFE2L2
Description		COP9 signalosome subunit 7A	nuclear factor, erythroid 2 like 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Protein-DNA Complex
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair COP9 Signalosome Assembly Viral Process Post-translational Protein Modification	Regulation Of Transcription By RNA Polymerase II Inflammatory Response Aging Response To Lithium Ion Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Viral Process Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Cellular Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Glutathione Biosynthetic Process Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS8 CPEB2 CSNK2A1 CSNK2B CUL5 EIF3E GPS1 KRT19P3 NFE2L2 PMF1 PPBP PRKD1 PTGS2 RAF1 TOM1L1 TP53	37 interacting genes: ATF4 BPTF CASP1 CASP3 CDH1 CHD6 COPS7A CREB3 CREBBP DCAF11 EIF2AK3 GSK3B JUN JUND KDM1A KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 MAPK8 NCOR2 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX SUMO1 SUMO2 TNNT1 TRIM24 UBE2E2 WAC
Entrez ID		50813	4780
HPRD ID		16736	02732
Ensembl ID		ENSG00000111652	ENSG00000116044
Uniprot IDs		Q9UBW8	Q16236
PDB IDs		4D10 4D18 4WSN	2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V
Enriched GO Terms of Interacting Partners?
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