COPS4 and PEX14

Data Source:
BioGRID (two hybrid)

		COPS4	PEX14
Description		COP9 signalosome subunit 4	peroxisomal biogenesis factor 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Post-translational Protein Modification	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Ubiquitination Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Metabolite levels ( 23823483)	Asthma ( 27182965 32296059) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		24 interacting genes: BRME1 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS7B COPS8 CUL5 FOS GPS1 IKBKB IL1RN KRT19 MBIP PCDHB12 PEX14 RBX1 RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ	14 interacting genes: CENPK COPS4 GET3 HDAC1 MARF1 MED8 MTNR1A NFE2 PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1
Entrez ID		51138	5195
HPRD ID		09888	03477
Ensembl ID		ENSG00000138663	ENSG00000142655
Uniprot IDs		A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78	O75381
PDB IDs		4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	2W84 2W85 4BXU
Enriched GO Terms of Interacting Partners?
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