KCNK4 and ORMDL1

Data Source:
BioGRID (two hybrid)

		KCNK4	ORMDL1
Description		potassium two pore domain channel subfamily K member 4	ORMDL sphingolipid biosynthesis regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Potassium Channel Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane SPOTS Complex
	Molecular Function	Voltage-gated Ion Channel Activity Potassium Channel Activity Potassium Ion Leak Channel Activity Temperature-gated Cation Channel Activity Mechanosensitived Potassium Channel Activity	Protein Binding
	Biological Process	Potassium Ion Transport Memory Sensory Perception Of Pain Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		TWIK related potassium channel (TREK) Phase 4 - resting membrane potential	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Sarcoidosis ( 22837380) Vitiligo ( 27723757)	Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		3 interacting genes: DIDO1 ORMDL1 RPL14	37 interacting genes: APP AQP6 ARL13B ASGR2 COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 GPR152 HSD17B11 KCNK4 LMNA LNX1 MFSD14B PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35C2 STOM TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		50801	94101
HPRD ID		12037	15092
Ensembl ID		ENSG00000182450	ENSG00000128699
Uniprot IDs		A0A024R5C7 Q2YDA1 Q9NYG8	Q9P0S3
PDB IDs		3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH
Enriched GO Terms of Interacting Partners?
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