PA2G4 and SIN3A

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PA2G4	SIN3A
Description		proliferation-associated 2G4	SIN3 transcription regulator family member A
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleolus Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Nucleolus Sin3 Complex Transcription Repressor Complex
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding Transcription Regulator Inhibitor Activity
	Biological Process	RRNA Processing Regulation Of Translation Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Protein Deacetylation Aging Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Regulation Of Lipid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Axon Extension Positive Regulation Of Chromatin Silencing Cellular Protein Localization Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Cellular Response To Dopamine Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Neutrophil degranulation	SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Refractive error ( 32231278) Vitiligo ( 22951725)	Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)
Interacting Genes		21 interacting genes: AR ATR ERBB3 ESR1 EXOSC5 HDAC2 HMGA1 HMGA2 HSPA4 IKBKG LIG4 MTOR PRKCA PRKCB PRKCG RB1 RNF20 SIN3A STUB1 SUMO4 TERF1	98 interacting genes: ARID4A ARID4B BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NCOR2 NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16
Entrez ID		5036	25942
HPRD ID		03685	09690
Ensembl ID		ENSG00000170515	ENSG00000169375
Uniprot IDs		A0A024RB85 Q9UQ80	Q96ST3
PDB IDs		2Q8K 3J2I 6CHT 6LSR 6SXO 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO	1PO4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?