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MS4A13 and EREG
Data Source:
BioGRID
(two hybrid)
MS4A13
EREG
Description
membrane spanning 4-domains A13
epiregulin
Image
No pdb structure
GO Annotations
Cellular Component
Integral Component Of Membrane
Extracellular Region
Extracellular Space
Integral Component Of Plasma Membrane
Clathrin-coated Vesicle Membrane
Molecular Function
Protein Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
MAPK Cascade
Angiogenesis
Ovarian Cumulus Expansion
Oocyte Maturation
Positive Regulation Of Cytokine Production
Female Meiotic Nuclear Division
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
MRNA Transcription
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Cytokine-mediated Signaling Pathway
Keratinocyte Differentiation
Ovulation
Positive Regulation Of Interleukin-6 Production
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Wound Healing
Positive Regulation Of Phosphorylation
Luteinizing Hormone Signaling Pathway
Response To Peptide Hormone
Keratinocyte Proliferation
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA Replication
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Primary Follicle Stage
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Membrane Organization
Regulation Of Cell Motility
Pathways
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
Congenital heart disease (maternal effect) (
28468790
)
Major depressive disorder (
29317602
)
Metabolite levels (X-11787) (
23934736
)
Attention deficit hyperactivity disorder (
18821565
)
Breast size (
22747683
)
Metabolite levels (
22916037
)
Interacting Genes
61 interacting genes:
AQP2
AQP6
ASGR2
ATP6V0E1
BEST1
BIK
CBARP
CD79A
CLDN7
CREB3L1
CREB3L3
DAGLA
EBP
EDA
EREG
ERGIC3
EVA1A
FAM209A
FAM210B
FFAR2
GJA4
GJA5
GJA8
GJB1
GJB5
GJB6
GJC3
GPR152
HERPUD2
JSRP1
KCNMB4
KLRC1
LHFPL5
LRRC3B
MMGT1
MS4A3
NPDC1
ODF4
POMK
RAMP1
RHCG
RNF185
SCN3B
SLC12A7
SLC13A4
SLC16A2
SLC18A1
SLC30A2
SLC39A2
SLC7A1
SPAG4
SSMEM1
TBXA2R
TLCD4
TM4SF18
TMC4
TMEM14B
TMEM237
TMEM52B
TMEM74
VSIR
6 interacting genes:
CXCL9
EGFR
ERBB4
MS4A13
NINJ2
OLFM4
Entrez ID
503497
2069
HPRD ID
17604
03638
Ensembl ID
ENSG00000204979
ENSG00000124882
Uniprot IDs
Q5J8X5
O14944
PDB IDs
1K36
1K37
5E8D
5WB7
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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