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OPRM1 and CLEC7A
Data Source:
BioGRID
(two hybrid)
OPRM1
CLEC7A
Description
opioid receptor mu 1
C-type lectin domain containing 7A
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Axon
Dendrite
Dendrite Membrane
Dendrite Cytoplasm
Sarcolemma
Neuron Projection
Perikaryon
Membrane Raft
Spine Apparatus
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Cytoplasm
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Molecular Function
G-protein Alpha-subunit Binding
G Protein-coupled Receptor Activity
Beta-endorphin Receptor Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Filamin Binding
G-protein Beta-subunit Binding
Morphine Receptor Activity
Peptide Binding
Neuropeptide Binding
(1->3)-beta-D-glucan Binding
Protein Binding
Carbohydrate Binding
Pattern Recognition Receptor Activity
MHC Protein Binding
Metal Ion Binding
Biological Process
Acute Inflammatory Response To Antigenic Stimulus
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Sensory Perception
Negative Regulation Of Cell Population Proliferation
Response To Radiation
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Response To Food
Positive Regulation Of Appetite
Response To Lipopolysaccharide
Opioid Receptor Signaling Pathway
Wound Healing
Response To Cocaine
Eating Behavior
Estrous Cycle
Behavioral Response To Ethanol
Positive Regulation Of Neurogenesis
Regulation Of Sensory Perception Of Pain
Excitatory Postsynaptic Potential
Negative Regulation Of Wnt Protein Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Response To Growth Factor
Cellular Response To Morphine
Regulation Of Cellular Response To Stress
Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of NMDA Receptor Activity
Leukocyte Activation Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Phagocytosis, Recognition
Inflammatory Response
Cell Recognition
Positive Regulation Of Cell Population Proliferation
Carbohydrate Mediated Signaling
Positive Regulation Of Gene Expression
Detection Of Fungus
Positive Regulation Of Cell Migration
Positive Regulation Of Protein-containing Complex Assembly
Detection Of Molecule Of Fungal Origin
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Superoxide Anion Generation
T Cell Activation
Defense Response To Protozoan
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Killing Of Cells Of Other Organism
Positive Regulation Of Respiratory Burst
Cellular Response To Molecule Of Fungal Origin
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Wound Healing
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cell Maturation
Pathways
Opioid Signalling
G-protein activation
Peptide ligand-binding receptors
G alpha (i) signalling events
Interleukin-4 and Interleukin-13 signaling
MECP2 regulates neuronal receptors and channels
CLEC7A (Dectin-1) signaling
CLEC7A (Dectin-1) signaling
Drugs
Tramadol
Morphine
Codeine
Amitriptyline
Hydromorphone
Methadone
Meperidine
Oxycodone
Levallorphan
Dextromethorphan
Butorphanol
Dextropropoxyphene
Pentazocine
Naltrexone
Sufentanil
Alfentanil
Fentanyl
Loperamide
Nalbuphine
Levorphanol
Remifentanil
Ondansetron
Anileridine
Buprenorphine
Hydrocodone
Diphenoxylate
Naloxone
Oxymorphone
Dezocine
Ketamine
Levacetylmethadol
Aripiprazole
Methadyl acetate
3-Methylthiofentanyl
Dimethylthiambutene
Diamorphine
Ethylmorphine
Etorphine
Carfentanil
Diprenorphine
Dihydromorphine
3-Methylfentanyl
V1003
Epicept NP-1
LI-301
Tapentadol
Nalmefene
Alvimopan
Morphine glucuronide
Ketobemidone
Methylnaltrexone
Naloxegol
Cannabidiol
Trimebutine
Butyrfentanyl
Pholcodine
Eluxadoline
Tianeptine
Opium
Pentoxyverine
Naldemedine
Metenkefalin
Medical Cannabis
Nabiximols
Loxicodegol
Oliceridine
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Adult body size (
32376654
)
Body size at age 10 (
32376654
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Hypertension (
21347282
)
Lipoprotein (a) levels (
26377243
)
Menstruation quality of life impact (fever) (
29855537
)
Methadone dose in opioid dependence (
28115739
)
Opioid use disorder (
32492095
)
Type 2 diabetes (age of onset) (
28060188
)
Interacting Genes
77 interacting genes:
ADAM33
ADD3
ALOX5AP
ATP6V0C
ATP6V0E1
C2CD2L
CALM1
CCDC167
CD302
CLCN7
CLDN10
CLDN22
CLDN8
CLEC12B
CLEC7A
CNIH1
COPS5
CPLX1
CTXN3
CYB561
DNAJB4
DOK4
DOK5
EHHADH
EMP1
EMP3
FLNA
GJA4
GNA15
GNAI1
GNAI2
GNAO1
GPRASP1
GRK3
GRM1
HS6ST1
IFITM3
KCNF1
LAT
LPAR3
LRRC25
MAL
MALL
MAP1LC3A
MAP1LC3C
MFF
NELFA
NSG1
OPRD1
OPRL1
PLD2
PLD3
PMP22
PPL
RPRM
RTP4
SCGB1D1
SEC22A
SERP2
SIAH1
SIAH2
SLC30A2
SLC38A7
SLC39A13
SLC41A1
SLC9A9
SMAGP
TEX264
TM4SF4
TMBIM6
TMEM236
TRARG1
UBC
VAPA
WLS
YIPF3
ZYX
47 interacting genes:
ADAM33
AIP
ARL13B
ASGR2
BNIP3
BNIP3L
C14orf180
CALM3
CD53
CD74
CTXN3
CXCL9
FAM3A
FCGR1A
FNDC9
GJB1
HSPD1
IFNGR2
IL1RL1
JAGN1
KLRC1
KTN1
MTIF3
NEMP1
NINJ2
NSG2
OCLN
OLFM4
OPRM1
PTTG1IP
RANBP9
RHOU
SAR1A
SEC22A
SGCB
SMIM3
SPINT1
SUSD3
SYNE4
TEX29
TLCD4
TMEM79
TMPRSS2
TMPRSS4
UPK2
VSIR
ZFPL1
Entrez ID
4988
64581
HPRD ID
02484
08396
Ensembl ID
ENSG00000112038
ENSG00000172243
Uniprot IDs
B8K2Q5
G8XRH4
G8XRH5
L0E130
P35372
A0A024RAN9
A0A0S2Z5Q1
Q68D78
Q9BXN2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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