NRGN and EIF5

Data Source:
BioGRID (two hybrid)

		NRGN	EIF5
Description		neurogranin	eukaryotic translation initiation factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Trans-Golgi Network Transport Vesicle Membrane Postsynaptic Density Axon Mitochondrial Membrane Neuronal Cell Body Dendritic Spine Head Postsynaptic Membrane Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidic Acid Binding	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding
	Biological Process	Signal Transduction Nervous System Development Associative Learning Telencephalon Development Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity
Pathways		Long-term potentiation Long-term potentiation	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 28991256 25056061 19571808 29483656 30285260)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		6 interacting genes: CALM1 EIF5 GLP1R PRKCA PRKCB PRKCG	16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1
Entrez ID		4900	1983
HPRD ID		03828	03417
Ensembl ID		ENSG00000154146	ENSG00000100664
Uniprot IDs		A0A024R3M7 Q92686	A0A024R6Q1 P55010
PDB IDs			2E9H 2G2K 2IU1
Enriched GO Terms of Interacting Partners?
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