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NFKBIE and HDAC5
Data Source:
BioGRID
(pull down)
NFKBIE
HDAC5
Description
NFKB inhibitor epsilon
histone deacetylase 5
Image
No pdb structure
GO Annotations
Cellular Component
Fibrillar Center
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Perinuclear Region Of Cytoplasm
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Speck
Molecular Function
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
Chromatin Binding
Histone Deacetylase Activity
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
Repressing Transcription Factor Binding
Biological Process
D-serine Transport
Cytoplasmic Sequestering Of Transcription Factor
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Chromatin Silencing
Protein Deacetylation
Inflammatory Response
Regulation Of Myotube Differentiation
Negative Regulation Of Myotube Differentiation
Response To Activity
Histone Deacetylation
Neuron Differentiation
B Cell Differentiation
Cellular Response To Insulin Stimulus
Regulation Of Gene Expression, Epigenetic
B Cell Activation
Response To Cocaine
Response To Drug
Regulation Of Protein Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Histone H3 Deacetylation
Cellular Response To Lipopolysaccharide
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Histone H3-K9 Acetylation
Pathways
Activation of NF-kappaB in B cells
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Belinostat
Panobinostat
Diseases
Hodgkin lymphoma
GWAS
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Rheumatoid arthritis (
30423114
22446963
23028356
24390342
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
31043756
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (spine) (
19801982
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
28869591
)
Mean platelet volume (
32888494
)
Interacting Genes
15 interacting genes:
ANKHD1
C1QBP
CUL1
HDAC4
HDAC5
IL1A
JUP
KBTBD7
NCOR2
NFKB1
NFKB2
PPP6C
REL
RELA
SKP1
61 interacting genes:
ANKRA2
ANKRD11
ATF3
BCL6
BCOR
BRMS1
CAMK1
CAMTA2
CBX5
CIITA
CTBP1
DDX20
DYRK1B
EEF1G
ESR1
GABARAP
GATA1
GATA2
GCM1
GNB1
H3C1
HDAC3
HDAC7
HIF1A
HOXC11
HR
JDP2
KLF4
LMO2
MAFF
MEF2A
MEF2C
MEF2D
NCOR1
NCOR2
NFATC1
NFKB2
NFKBIE
NRIP1
PHB2
PKN1
PKN2
PRKAA1
PRKCD
PRKD1
RFXANK
RUNX3
SFN
SIK1
SIK2
SIK3
SLC2A4RG
SMAD3
SUV39H1
TAB2
UBC
UBE2I
YWHAB
YWHAE
YWHAQ
ZBTB16
Entrez ID
4794
10014
HPRD ID
05181
09246
Ensembl ID
ENSG00000146232
ENSG00000108840
Uniprot IDs
A0A024RD24
O00221
Q7LC14
Q96F31
Q9UQL6
PDB IDs
5UWI
Enriched GO Terms of Interacting Partners
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