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NFKBIE and CUL1
Data Source:
HPRD
(in vitro)
NFKBIE
CUL1
Description
NFKB inhibitor epsilon
cullin 1
Image
No pdb structure
GO Annotations
Cellular Component
Fibrillar Center
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Perinuclear Region Of Cytoplasm
Nucleoplasm
Cytosol
Plasma Membrane
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
D-serine Transport
Cytoplasmic Sequestering Of Transcription Factor
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Monoubiquitination
Cellular Iron Ion Homeostasis
Cell Population Proliferation
Animal Organ Morphogenesis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Hodgkin lymphoma
GWAS
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Rheumatoid arthritis (
30423114
22446963
23028356
24390342
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
15 interacting genes:
ANKHD1
C1QBP
CUL1
HDAC4
HDAC5
IL1A
JUP
KBTBD7
NCOR2
NFKB1
NFKB2
PPP6C
REL
RELA
SKP1
56 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CHEK1
CHUK
CKS1B
COMMD1
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
Entrez ID
4794
8454
HPRD ID
05181
04389
Ensembl ID
ENSG00000146232
ENSG00000055130
Uniprot IDs
A0A024RD24
O00221
Q7LC14
Q96F31
A0A090N7U0
B3KTW0
Q13616
PDB IDs
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
6TTU
6WCQ
Enriched GO Terms of Interacting Partners
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