NEFH and NEFM

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		NEFH	NEFM
Description		neurofilament heavy	neurofilament medium
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Neurofilament Postsynaptic Density Axon Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton	Neurofilament Axon Intermediate Filament Cytoskeleton Neurofibrillary Tangle
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor	Neurofilament Bundle Assembly
Pathways
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Brain morphology (MOSTest) ( 32665545) Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1	12 interacting genes: APOE DISC1 DRD2 FOS MINK1 NEFH NEFL RB1 SMAD2 STXBP1 TNIK VIM
Entrez ID		4744	4741
HPRD ID		01204	01205
Ensembl ID		ENSG00000100285	ENSG00000104722
Uniprot IDs		P12036	P07197 Q9UK51
PDB IDs
Enriched GO Terms of Interacting Partners?
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