NEFM and NEFH

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		NEFM	NEFH
Description		neurofilament medium	neurofilament heavy
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Neurofilament Axon Intermediate Filament Cytoskeleton Neurofibrillary Tangle	Cytoplasm Cytoskeleton Neurofilament Postsynaptic Density Axon Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Neurofilament Bundle Assembly	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor
Pathways
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Brain morphology (MOSTest) ( 32665545) Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)
Interacting Genes		12 interacting genes: APOE DISC1 DRD2 FOS MINK1 NEFH NEFL RB1 SMAD2 STXBP1 TNIK VIM	6 interacting genes: ERBB2 MAPK1 NEFL NEFM PKN1 STXBP1
Entrez ID		4741	4744
HPRD ID		01205	01204
Ensembl ID		ENSG00000104722	ENSG00000100285
Uniprot IDs		P07197 Q9UK51	P12036
PDB IDs
Enriched GO Terms of Interacting Partners?
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