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NEFH and NEFL
Data Source:
HPRD
(in vitro)
NEFH
NEFL
Description
neurofilament heavy
neurofilament light
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Neurofilament
Postsynaptic Density
Axon
Neurofibrillary Tangle
Schaffer Collateral - CA1 Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Cytoplasm
Cytosol
Neurofilament
Axon
Growth Cone
Neuromuscular Junction
Schaffer Collateral - CA1 Synapse
Cholinergic Synapse
Postsynaptic Intermediate Filament Cytoskeleton
Presynaptic Intermediate Filament Cytoskeleton
Axon Cytoplasm
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Microtubule Binding
Kinesin Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Dynein Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Structural Constituent Of Cytoskeleton
Protein Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
Biological Process
Microtubule Cytoskeleton Organization
Axonogenesis
Cell Projection Assembly
Neurofilament Bundle Assembly
Peripheral Nervous System Neuron Axonogenesis
Neurofilament Cytoskeleton Organization
Axon Development
Postsynaptic Intermediate Filament Cytoskeleton Organization
Regulation Of Organelle Transport Along Microtubule
Cellular Response To Leukemia Inhibitory Factor
MAPK Cascade
Microtubule Cytoskeleton Organization
Anterograde Axonal Transport
Retrograde Axonal Transport
Response To Toxic Substance
Peripheral Nervous System Axon Regeneration
Axonal Transport Of Mitochondrion
Spinal Cord Development
Hippocampus Development
Cerebral Cortex Development
Regulation Of Axon Diameter
Neurofilament Bundle Assembly
Locomotion
Response To Peptide Hormone
Negative Regulation Of Neuron Apoptotic Process
Intermediate Filament Polymerization Or Depolymerization
Intermediate Filament Organization
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Neuromuscular Process Controlling Balance
Protein Polymerization
Response To Corticosterone
Neurofilament Cytoskeleton Organization
Synapse Maturation
Postsynaptic Intermediate Filament Cytoskeleton Organization
Response To Sodium Arsenite
Response To Acrylamide
Regulation Of NMDA Receptor Activity
Pathways
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Fear of minor pain (
28701861
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) (
24554482
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Interacting Genes
6 interacting genes:
ERBB2
MAPK1
NEFL
NEFM
PKN1
STXBP1
50 interacting genes:
BRD7
CCDC13
CCDC172
CCDC33
CCNC
CDK5RAP2
CEP57L1
CHD3
DES
ENKD1
GFAP
GOLGA2
GORASP1
GRIN1
HGS
KDM1A
KIFC3
KLC3
KRT13
KRT15
KRT18
MAP2
MTMR2
MTUS2
MYO15B
MYO5A
NDN
NEFH
NEFM
NEK6
NME7
PDE4DIP
PIAS4
PKN1
PPP1R16B
PPP1R18
PRMT6
SKIL
SMYD1
SPTAN1
TERF1
TEX11
TRIM55
TRIM63
TSC1
TXLNB
USHBP1
USP2
VIM
YWHAG
Entrez ID
4744
4747
HPRD ID
01204
01206
Ensembl ID
ENSG00000100285
ENSG00000277586
Uniprot IDs
P12036
P07196
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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