NDUFS4 and UBE2G2

Data Source:
BioGRID (two hybrid)

		NDUFS4	UBE2G2
Description		NADH:ubiquinone oxidoreductase subunit S4	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Regulation Of Protein Phosphorylation Mitochondrial Electron Transport, NADH To Ubiquinone Brain Development CAMP-mediated Signaling Mitochondrial Respiratory Chain Complex I Assembly Cellular Respiration Positive Regulation Of Fibroblast Proliferation Response To CAMP Reactive Oxygen Species Metabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Respiratory electron transport Complex I biogenesis	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Midgestational circulating levels of PCBs ( 28235828) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Verbal memory ( 29907492) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		2 interacting genes: APP UBE2G2	39 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		4724	7327
HPRD ID		04073	04387
Ensembl ID		ENSG00000164258	ENSG00000184787
Uniprot IDs		A0A0S2Z433 O43181	P60604
PDB IDs		5XTB 5XTD 5XTH 5XTI	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?
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