ATIC and SERPINB5

Data Source:
BioGRID (two hybrid)

		ATIC	SERPINB5
Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	serpin family B member 5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Cytoplasm
	Molecular Function	IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Protein Homodimerization Activity Cadherin Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process 'de Novo' IMP Biosynthetic Process Nucleoside Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Inorganic Substance Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Cellular Response To Interleukin-7	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways		Purine ribonucleoside monophosphate biosynthesis
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid	S,S-(2-Hydroxyethyl)Thiocysteine
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		5 interacting genes: EGFR LINC01554 MTNR1A PRNP SERPINB5	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3
Entrez ID		471	5268
HPRD ID		03434	01111
Ensembl ID		ENSG00000138363	ENSG00000206075
Uniprot IDs		P31939 V9HWH7	A0A024R2B6 P36952
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?
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