NBN and CDK9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		NBN	CDK9
Description		nibrin	cyclin dependent kinase 9
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Nucleolus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body	Nucleus Nucleoplasm Transcription Elongation Factor Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Membrane Mediator Complex PML Body Cytoplasmic Ribonucleoprotein Granule P-TEFb Complex
	Molecular Function	Damaged DNA Binding Protein Binding Transcription Factor Binding Protein N-terminus Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Protein Kinase Binding 7SK SnRNA Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Blastocyst Growth DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Arrest Mitotic G2 DNA Damage Checkpoint Cell Population Proliferation Viral Process Regulation Of DNA-dependent DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Signal Transduction In Response To DNA Damage Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping	DNA Repair Regulation Of DNA Repair Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Regulation Of Mitotic Cell Cycle Cell Population Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Histone Modification Replication Fork Processing Positive Regulation Of Histone Phosphorylation Response To Drug SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Muscle Cell Differentiation Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Negative Regulation Of MRNA Polyadenylation Positive Regulation Of MRNA 3'-UTR Binding Positive Regulation Of Histone H2B Ubiquitination
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
Drugs			Alvocidib Seliciclib
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494)	Body mass index ( 26426971)
Interacting Genes		35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NAT2 NCL PRKDC RAD18 RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5	58 interacting genes: ACTL6A AFF4 AR BCL10 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CEBPB CTDP1 CTDSPL CUL1 DHX30 EEF1D FBXO25 GRN GTF2F1 H2BC21 HEXIM1 HEXIM2 HLTF HSPA1A HTATSF1 IL6ST LBX2 MBP MDFIC MED21 MYBL2 MYC NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6
Entrez ID		4683	1025
HPRD ID		04050	16016
Ensembl ID		ENSG00000104320	ENSG00000136807
Uniprot IDs		A0A0C4DG07 O60934	A0A024R880 P50750
PDB IDs		5WQD	1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH
Enriched GO Terms of Interacting Partners?
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