Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
NTAQ1 and POMC
Data Source:
BioGRID
(two hybrid)
NTAQ1
POMC
Description
N-terminal glutamine amidase 1
proopiomelanocortin
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Extracellular Region
Extracellular Space
Cytoplasm
Secretory Granule
Secretory Granule Lumen
Molecular Function
Protein Binding
Protein-N-terminal Asparagine Amidohydrolase Activity
Protein-N-terminal Glutamine Amidohydrolase Activity
G Protein-coupled Receptor Binding
Signaling Receptor Binding
Hormone Activity
Protein Binding
Type 3 Melanocortin Receptor Binding
Type 4 Melanocortin Receptor Binding
Type 1 Melanocortin Receptor Binding
Biological Process
Cellular Protein Modification Process
Generation Of Precursor Metabolites And Energy
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Cell-cell Signaling
Regulation Of Blood Pressure
Cytokine-mediated Signaling Pathway
Regulation Of Appetite
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Pigmentation
Glucose Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Glycogen Metabolic Process
Regulation Of Corticosterone Secretion
Pathways
Opioid Signalling
Androgen biosynthesis
Glucocorticoid biosynthesis
G-protein activation
Peptide hormone biosynthesis
Endogenous sterols
Peptide ligand-binding receptors
G alpha (s) signalling events
G alpha (i) signalling events
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Interleukin-4 and Interleukin-13 signaling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Loperamide
Etorphine
Dihydromorphine
Diseases
GWAS
Body mass index (
26426971
23669352
20935630
)
Body mass index (age <50) (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Crohn's disease (
28067908
)
Height (
28552196
23563607
18391951
)
Inflammatory bowel disease (
28067908
)
Obesity (
23563607
)
Pubertal anthropometrics (
23449627
)
Red vs. brown/black hair color (
30531825
)
Type 1 diabetes (
21980299
)
Interacting Genes
380 interacting genes:
AARD
ACD
ACOT13
ACTB
ACTG1
ACTN2
ACY1
ADAMTSL4
AGR2
AGR3
AIMP2
AKIRIN2
AMOT
AMOTL2
AMPD2
ANKRD11
ANKRD36B
AOC1
APIP
ARID4B
ARL6IP1
ASL
ATP6V1G1
BANF2
BCL2L2-PABPN1
BEND5
BIRC7
BLMH
BLOC1S6
BLZF1
BOLA2
BOLA2B
BORCS6
BPIFB3
BTBD1
BTBD2
BTBD6
C1orf50
CAMK2A
CAPN3
CARD9
CASP6
CAVIN4
CBFA2T2
CBS
CBY2
CCDC102B
CCDC115
CCDC152
CCDC184
CCDC197
CCHCR1
CCNB1IP1
CD22
CDA
CDCA8
CDK2AP1
CDKN2AIPNL
CDR2
CENPP
CEP170B
CEP55
CEP70
CEP85
CGGBP1
CHCHD3
CHMP4A
CMTM5
COG6
COIL
CRYAA
CRYAA2
CSNK2B
CT45A1
CTAG1A
CTAG1B
CTBP1
CTH
CUEDC1
CUTC
CYSRT1
DAB1
DCTPP1
DEUP1
DHPS
DNAL4
DNM2
DYNLT1
EDARADD
EGLN3
EIF2B1
EIF4G1
EMILIN3
ENOX2
EP400
EPN3
ETV6
EXOSC8
FAM136A
FAM72A
FAM72D
FKBP6
FTH1
FTL
GADD45GIP1
GAS7
GCSAML
GFAP
GMCL1
GMDS
GNG3
GNMT
GNPDA2
GOLGA2
GOLGA6L9
GPX7
GRAMD4
GSTA4
GSTO2
GTF2H2C
H2AP
HAUS8
HBQ1
HBZ
HEATR5A
HGD
HIGD1C
HMG20A
HOMER3
HOXB6
HPRT1
HSD17B14
HSF2BP
HSPE1
HUS1
IKZF3
IL16
IL31
INCA1
ISCA2
ITGB3BP
JAKMIP2
JUP
KASH5
KATNBL1
KCNH1
KCTD1
KCTD10
KCTD13
KCTD15
KCTD21
KCTD4
KCTD6
KCTD7
KCTD9
KEAP1
KIF21B
KLHL12
KLHL2
KLHL20
KRT27
KRT31
KRTAP10-5
KRTAP10-7
KRTAP19-2
KRTAP19-6
KRTAP3-1
KRTAP3-3
KRTAP4-2
KRTAP5-9
KRTAP6-1
KRTAP9-2
KRTAP9-4
KRTAP9-8
L3MBTL3
LCE1C
LCE1D
LCE1E
LCE1F
LCE2C
LCE5A
LDB2
LENG1
LGALS2
LGALS9B
LIN7B
LMNA
LMO1
LMO2
LMO3
LNX2
LONRF1
LRIF1
LRRC73
LSM12
LSM14B
LZTFL1
LZTS1
LZTS2
MAB21L3
MAD1L1
MAGEA11
MAGEA12
MAGEA2
MAGEA2B
MALSU1
MARCHF10
MATN4
MDFI
MED22
MIF
MIF4GD
MIOS
MIPOL1
MIS18A
MITD1
MOB2
MORN3
MPLKIP
MRFAP1L1
MRPL12
MTHFD2L
MTUS2
MVP
MXRA8
MYD88
N4BP3
NAB2
NADSYN1
NAGK
NCOA5
NDUFAB1
NECAB2
NME1
NPL
NR5A1
NT5C1A
NTAN1
NUDT14
NUDT16L1
NUDT21
OOEP
PAK5
PCBD1
PFDN5
PGPEP1
PIH1D2
PLA2G10
PLCD1
PLEKHB2
PLEKHJ1
PNMA1
PNMA2
PNMA5
POLR2J
POMC
PPCDC
PPM1K
PPP1R27
PRKAR1B
PRMT1
PRMT5
PRPS2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR23B
PRTFDC1
PSMB5
PSME3
PTS
PYCR3
PYGM
RAB42
RABAC1
RASAL3
RBBP8
RBM20
RBM45
RBM48
RBPMS
RD3
REEP6
RHOQ
RILPL1
RNF138
RNF4
ROPN1
RPIA
RUSC1
S100A11
SAP18
SARS2
SAT1
SCARA5
SELENOV
SEPTIN14
SEPTIN3
SFN
SH3GLB2
SIAH1
SIKE1
SIVA1
SLAIN1
SLC15A2
SLPI
SMAP1
SMN1
SNAP29
SNRPD3
SPANXB1
SPATA32
SPDYE4
SPINDOC
SPRYD7
SSNA1
SSX2IP
STH
STMN2
STN1
STX11
SYCE1L
SYNGAP1
TAX1BP1
TBX15
TCL1A
TCP10L
TEKT1
TEPSIN
THAP1
THAP6
THAP7
THG1L
TICAM2
TIFA
TLE5
TMEM239
TNFAIP1
TNIP3
TNR
TOLLIP
TRAF1
TRAF3
TRAF5
TRIM23
TRIM27
TRIM32
TRIM5
TRIM54
TRIM69
TRIM73
TRIM9
TRIP13
TSC22D1
TSN
TSNAX
UBR1
UBR2
UFC1
UNKL
VAC14
VCP
VDR
VPS37C
VXN
XIAP
ZBED1
ZBTB8A
ZBTB8B
ZC2HC1C
ZCCHC17
ZNF165
ZNF341
ZNF436
ZNF511
ZNF618
ZSCAN16
ZSCAN32
28 interacting genes:
ABI2
APP
ATP6V0D2
BHLHA9
C1orf109
CCDC102B
ESRRG
FGF10
GLYCTK
HDDC2
HLA-DRB3
HSF2BP
KLHL42
MC1R
MC2R
MC3R
MC4R
MC5R
MEP1A
MKRN3
NFKBID
NRDC
NTAQ1
OAZ3
PAM
SUOX
TXN2
VTN
Entrez ID
55093
5443
HPRD ID
07653
01462
Ensembl ID
ENSG00000156795
ENSG00000115138
Uniprot IDs
A0A3B3ITD7
A0A3B3ITI2
E5RHC2
Q96HA8
P01189
PDB IDs
3C9Q
4W79
6KGJ
4XNH
4XPD
4Y49
6TUB
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?