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MTNR1A and SOX11
Data Source:
BioGRID
(two hybrid)
MTNR1A
SOX11
Description
melatonin receptor 1A
SRY-box transcription factor 11
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Chromatin
Nucleus
Nucleoplasm
Plasma Membrane
Molecular Function
G Protein-coupled Receptor Activity
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Biological Process
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Mating Behavior
Circadian Rhythm
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Kidney Development
Neural Tube Formation
Lens Morphogenesis In Camera-type Eye
Outflow Tract Morphogenesis
Cardiac Ventricle Formation
Noradrenergic Neuron Differentiation
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Oligodendrocyte Development
Glial Cell Proliferation
Neural Crest Cell Development
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Spinal Cord Development
Glial Cell Development
Cell Differentiation
Neuron Differentiation
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Hippo Signaling
Skeletal Muscle Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Secretion
Sympathetic Nervous System Development
Embryonic Digestive Tract Morphogenesis
Embryonic Skeletal System Morphogenesis
Negative Regulation Of Lymphocyte Proliferation
Positive Regulation Of Neurogenesis
Hard Palate Development
Soft Palate Development
Limb Bud Formation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Lung Morphogenesis
Negative Regulation Of Cell Death
Neuroepithelial Cell Differentiation
Eyelid Development In Camera-type Eye
Somite Development
Cornea Development In Camera-type Eye
Closure Of Optic Fissure
Signal Transduction Involved In Cell Cycle Checkpoint
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Lens Epithelial Cell Proliferation
Pathways
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Drugs
Ramelteon
Melatonin
Resveratrol
Agomelatine
Tasimelteon
Diseases
GWAS
Depressive symptoms measurement (somatic complaints domain) (
26997408
)
Job-related exhaustion in shift workers (
28364478
)
Obesity (
21552555
)
Automobile speeding propensity (
30643258
)
BMI (adjusted for smoking behaviour) (
28443625
)
BMI in non-smokers (
28443625
)
Body mass index (joint analysis main effects and smoking interaction) (
28443625
)
Chronic kidney disease (
20383146
)
Crohn's disease (
23266558
)
Diabetic kidney disease (
26305897
)
Hip circumference (
25673412
)
Intraocular pressure (
29617998
)
Obesity in adult survivors of childhood cancer exposed to cranial radiation (
25963547
)
Obesity-related traits (
23251661
)
Proteinuria and chronic kidney disease (
26420894
)
Tuberculosis (
24057671
)
Type 2 diabetes (
31118516
)
Interacting Genes
159 interacting genes:
ABHD14B
ACTB
ACTN1
AMOTL2
ANKRD12
ARHGAP28
ASAP3
ASCL1
ATIC
ATP5MC3
BAG6
BAZ1A
BAZ1B
C10orf90
CALR
CAND1
CANX
CCDC167
CD99
CHD4
CIAO2B
CIT
CLASP1
CMIP
CNP
COG1
COL9A2
COMT
COX11
CTNNA1
CTPS2
CUL3
CUL7
CYP27C1
CYSRT1
DDHD2
DDX52
DPM1
ECE1
ECE2
EEF1G
EMC7
EMD
ENO2
EPS15
EXOC1
F8A1
FAM241B
FDXR
FLNA
FN1
FSTL1
GALNS
GAPDH
GATAD2B
GBA2
GEMIN2
GFPT2
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
H2AC6
HDAC10
HIVEP2
HMGN2
HMOX2
HNRNPA0
HNRNPH1
HSPA5
IPO9
IRS4
ITPR3
KLHL12
KLHL20
KLHL5
KPNB1
KRTAP1-3
LAPTM4A
LIPE
LPP
LRP3
LRRC59
MAMLD1
MCC
MESD
MMP2
MMS19
MPDZ
MTNR1B
MYO9A
NAP1L1
NAP1L4
NAP1L5
NASP
PAXIP1
PCDHB10
PDIA6
PEX14
PGRMC1
PKD1L2
PPP2R3C
PRELID1
PSMD2
PSME4
PTPN13
PTPRD
PTX3
RAB10
RAC1
RACK1
RAP1A
RBM39
RGS12
RNF2
RNF41
RPL3
RTRAF
SLC2A3
SLC30A1
SLC6A3
SLIT1
SNAPIN
SOX11
SRI
STXBP1
SUCLA2
SURF4
SVEP1
TLN1
TM9SF1
TMEM14A
TMEM230
TMEM33
TMX2
TPP2
TRIP12
TUBB
TVP23B
UBA1
UBAP2L
UBQLN1
UBR4
USP28
USP32
USP34
VAPB
VARS1
WAPL
WASHC4
YWHAB
YWHAZ
ZC3H11A
ZDHHC16
ZNF460
3 interacting genes:
MTNR1A
POU3F2
POU3F3
Entrez ID
4543
6664
HPRD ID
02812
02940
Ensembl ID
ENSG00000168412
ENSG00000176887
Uniprot IDs
P48039
P35716
PDB IDs
6ME2
6ME3
6ME4
6ME5
6T78
6T7A
6T7C
6T7D
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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