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MTNR1A and PSME4
Data Source:
BioGRID
(two hybrid)
MTNR1A
PSME4
Description
melatonin receptor 1A
proteasome activator subunit 4
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Nucleus
Nucleoplasm
Cytosol
Nuclear Speck
Spermatoproteasome Complex
Molecular Function
G Protein-coupled Receptor Activity
Protein Binding
Melatonin Receptor Activity
Hormone Binding
Organic Cyclic Compound Binding
Protein Binding
Peptidase Activator Activity
Lysine-acetylated Histone Binding
Proteasome Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Mating Behavior
Circadian Rhythm
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
DNA Repair
Regulation Of Cellular Amino Acid Metabolic Process
Cellular Response To DNA Damage Stimulus
Multicellular Organism Development
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Peptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Spermatogenesis, Exchange Of Chromosomal Proteins
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Ramelteon
Melatonin
Resveratrol
Agomelatine
Tasimelteon
Diseases
GWAS
Depressive symptoms measurement (somatic complaints domain) (
26997408
)
Job-related exhaustion in shift workers (
28364478
)
Obesity (
21552555
)
Body mass index (
28892062
)
Chronotype (
30696823
27494321
)
Hand grip strength (
29691431
)
Morning vs. evening chronotype (
27494321
)
Refractive error (
32231278
)
Interacting Genes
159 interacting genes:
ABHD14B
ACTB
ACTN1
AMOTL2
ANKRD12
ARHGAP28
ASAP3
ASCL1
ATIC
ATP5MC3
BAG6
BAZ1A
BAZ1B
C10orf90
CALR
CAND1
CANX
CCDC167
CD99
CHD4
CIAO2B
CIT
CLASP1
CMIP
CNP
COG1
COL9A2
COMT
COX11
CTNNA1
CTPS2
CUL3
CUL7
CYP27C1
CYSRT1
DDHD2
DDX52
DPM1
ECE1
ECE2
EEF1G
EMC7
EMD
ENO2
EPS15
EXOC1
F8A1
FAM241B
FDXR
FLNA
FN1
FSTL1
GALNS
GAPDH
GATAD2B
GBA2
GEMIN2
GFPT2
GNA11
GNA13
GNAI1
GNAI2
GNAI3
GNB1
GNB4
GPR50
H2AC6
HDAC10
HIVEP2
HMGN2
HMOX2
HNRNPA0
HNRNPH1
HSPA5
IPO9
IRS4
ITPR3
KLHL12
KLHL20
KLHL5
KPNB1
KRTAP1-3
LAPTM4A
LIPE
LPP
LRP3
LRRC59
MAMLD1
MCC
MESD
MMP2
MMS19
MPDZ
MTNR1B
MYO9A
NAP1L1
NAP1L4
NAP1L5
NASP
PAXIP1
PCDHB10
PDIA6
PEX14
PGRMC1
PKD1L2
PPP2R3C
PRELID1
PSMD2
PSME4
PTPN13
PTPRD
PTX3
RAB10
RAC1
RACK1
RAP1A
RBM39
RGS12
RNF2
RNF41
RPL3
RTRAF
SLC2A3
SLC30A1
SLC6A3
SLIT1
SNAPIN
SOX11
SRI
STXBP1
SUCLA2
SURF4
SVEP1
TLN1
TM9SF1
TMEM14A
TMEM230
TMEM33
TMX2
TPP2
TRIP12
TUBB
TVP23B
UBA1
UBAP2L
UBQLN1
UBR4
USP28
USP32
USP34
VAPB
VARS1
WAPL
WASHC4
YWHAB
YWHAZ
ZC3H11A
ZDHHC16
ZNF460
4 interacting genes:
CALCOCO2
FBXL17
MTNR1A
NUTM1
Entrez ID
4543
23198
HPRD ID
02812
09652
Ensembl ID
ENSG00000168412
ENSG00000068878
Uniprot IDs
P48039
Q14997
PDB IDs
6ME2
6ME3
6ME4
6ME5
6KWX
6KWY
6REY
Enriched GO Terms of Interacting Partners
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