MTNR1A and CLASP1

Data Source:
BioGRID (two hybrid)

		MTNR1A	CLASP1
Description		melatonin receptor 1A	cytoplasmic linker associated protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Kinetochore Condensed Chromosome Kinetochore Golgi Apparatus Centrosome Microtubule Organizing Center Kinetochore Microtubule Cytosol Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	Dystroglycan Binding Protein Binding Microtubule Binding Kinetochore Binding Microtubule Plus-end Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Regulation Of G2/M Transition Of Mitotic Cell Cycle Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Extracellular Matrix Disassembly Establishment Of Epithelial Cell Polarity Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Fostamatinib
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Obesity ( 21552555)	Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)
Interacting Genes		159 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	11 interacting genes: CKAP5 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B SRPK2 SYBU YWHAG
Entrez ID		4543	23332
HPRD ID		02812	09322
Ensembl ID		ENSG00000168412	ENSG00000074054
Uniprot IDs		P48039	Q7Z460
PDB IDs		6ME2 6ME3 6ME4 6ME5	4K92 6MQ5 6MQ7
Enriched GO Terms of Interacting Partners?
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