MMP12 and TFPI

Data Source:
HPRD (in vitro)

		MMP12	TFPI
Description		matrix metallopeptidase 12	tissue factor pathway inhibitor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding Sequence-specific DNA Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Protein Import Into Nucleus Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Interferon-alpha Production Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Elastin Catabolic Process Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Bronchiole Development Cellular Response To Virus Response To Amyloid-beta Negative Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix	Extrinsic Pathway of Fibrin Clot Formation
Drugs		Acetohydroxamic acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic Acid AE-941 (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine CGS-27023 N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine	Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		Alzheimer's disease ( 22832961) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic obstructive pulmonary disease (severe) ( 24621683) Emphysema imaging phenotypes ( 26030696) Ischemic stroke ( 29531354) Ischemic stroke (large artery atherosclerosis) ( 29531354) Local histogram emphysema pattern ( 25006744) Peanut allergy ( 29030101) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Stroke ( 29531354)	Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		5 interacting genes: APP F12 LPA PLAUR TFPI	10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		4321	7035
HPRD ID		03027	01064
Ensembl ID		ENSG00000262406	ENSG00000003436
Uniprot IDs		P39900	P10646
PDB IDs		1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2MLR 2MLS 2N8R 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO 5CXA 5CZM 5D2B 5D3C 5I0L 5I2Z 5I3M 5I43 5I4O 5L79 5L7F 5LAB 5N5J 5N5K 6EKN 6ELA 6ENM 6EOX 6RD0 6RLY	1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8
Enriched GO Terms of Interacting Partners?
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