TFPI and PRSS3

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		TFPI	PRSS3
Description		tissue factor pathway inhibitor	serine protease 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Organelle Membrane Anchored Component Of Membrane	Extracellular Region Extracellular Space Tertiary Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus	Proteolysis Digestion Cobalamin Metabolic Process Antimicrobial Humoral Response Zymogen Activation Neutrophil Degranulation Endothelial Cell Migration
Pathways		Extrinsic Pathway of Fibrin Clot Formation	Alpha-defensins Cobalamin (Cbl, vitamin B12) transport and metabolism Neutrophil degranulation Antimicrobial peptides
Drugs		Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa	4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine Diamino-N-[3-(1,3,2-dioxaborolan-2-yloxy)propyl]methaniminium Guanidine-3-propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Bipolar disorder ( 20351715) Hand grip strength ( 29691431) Refractive error ( 32231278) Triglycerides ( 30275531)
Interacting Genes		10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	4 interacting genes: APP LINC00839 SERPINA1 TFPI
Entrez ID		7035	5646
HPRD ID		01064	06685
Ensembl ID		ENSG00000003436	ENSG00000010438
Uniprot IDs		P10646	P35030 Q7Z5F4
PDB IDs		1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8	1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4 4U30 4U32 5C67 5JBT 5TP0 6BX8 6GFI
Enriched GO Terms of Interacting Partners?
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