TFPI and MMP9

Data Source:
HPRD (in vitro)

		TFPI	MMP9
Description		tissue factor pathway inhibitor	matrix metallopeptidase 9
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Organelle Membrane Anchored Component Of Membrane	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus	Skeletal System Development Ossification Positive Regulation Of Protein Phosphorylation Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Positive Regulation Of Cell Migration Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Cellular Response To Cadmium Ion Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Binding Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cation Channel Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Extrinsic Pathway of Fibrin Clot Formation	Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling
Drugs		Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa	Glutathione Marimastat Minocycline Captopril Glucosamine Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)
Interacting Genes		10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1	31 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI THBS1 THBS2 TIMP3
Entrez ID		7035	4318
HPRD ID		01064	00387
Ensembl ID		ENSG00000003436	ENSG00000100985
Uniprot IDs		P10646	P14780
PDB IDs		1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8	1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM
Enriched GO Terms of Interacting Partners?
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