TFPI

Description		tissue factor pathway inhibitor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Organelle Membrane Anchored Component Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Blood Coagulation Blood Coagulation, Extrinsic Pathway Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus
Pathways		Extrinsic Pathway of Fibrin Clot Formation
Drugs		Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		7035
HPRD ID		01064
Ensembl ID		ENSG00000003436
Uniprot IDs		P10646
PDB IDs		1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8
Enriched GO Terms of Interacting Partners?
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