BCAN and TNR

Data Source:
HPRD (in vitro)

		BCAN	TNR
Description		brevican	tenascin R
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Anchored Component Of Membrane Lysosomal Lumen Glutamatergic Synapse	Extracellular Region Extracellular Space Cell Surface Membrane Raft Collagen-containing Extracellular Matrix Perineuronal Net Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Signaling Receptor Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Synapse Maturation	Cell Adhesion Neuron Cell-cell Adhesion Axon Guidance Associative Learning Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Locomotory Exploration Behavior Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	ECM proteoglycans
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Attention deficit hyperactivity disorder ( 30563984) Body mass index ( 26426971) Corneal astigmatism ( 29422769) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Telomere length ( 30185882) Tonometry ( 17903302)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	16 interacting genes: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC NTAQ1 POLR3C PSMA1 PTPRZ1 SIGLEC1 TRIM54 VCAN
Entrez ID		63827	7143
HPRD ID		02644	03589
Ensembl ID		ENSG00000132692	ENSG00000116147
Uniprot IDs		Q96GW7	A1L306 Q92752
PDB IDs
Enriched GO Terms of Interacting Partners?
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