BCAN and MMP10

Data Source:
HPRD (in vitro)

		BCAN	MMP10
Description		brevican	matrix metallopeptidase 10
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Extracellular Matrix Anchored Component Of Membrane Lysosomal Lumen Glutamatergic Synapse	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Synapse Maturation	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs			Marimastat N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	3 interacting genes: BCAN HAPLN1 MMP9
Entrez ID		63827	4319
HPRD ID		02644	01704
Ensembl ID		ENSG00000132692	ENSG00000166670
Uniprot IDs		Q96GW7	P09238
PDB IDs			1Q3A 3V96 4ILW
Enriched GO Terms of Interacting Partners?
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