MFGE8 and PSTPIP1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology)

		MFGE8	PSTPIP1
Description		milk fat globule EGF and factor V/VIII domain containing	proline-serine-threonine phosphatase interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Uropod Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding Integrin Binding Extracellular Matrix Structural Constituent Phosphatidylethanolamine Binding	Protein Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Angiogenesis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Single Fertilization Apoptotic Cell Clearance Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Phagocytosis	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Amyloid fiber formation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Blood protein levels ( 30072576 29875488 28240269) Coronary artery disease ( 32469254 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Height ( 31562340) Pulse pressure ( 27841878) Squamous cell lung carcinoma ( 28604730)	Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes			64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		4240	9051
HPRD ID		03789	05891
Ensembl ID		ENSG00000140545	ENSG00000140368
Uniprot IDs		B3KTQ2 B4E396 Q08431	A0A0S2Z5P3 O43586
PDB IDs			2DIL
Enriched GO Terms of Interacting Partners?
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